The antidepressants citalopram and reboxetine reduce seizure frequency in rats with chronic epilepsy
نویسندگان
چکیده
منابع مشابه
Correlation between Epilepsy Self-Management Behaviors and Seizure Frequency among Patients with Epilepsy in Iran Epilepsy Association
Background and Objectives: Epilepsy is a chronic condition results in seizure and leads to debilitating conditions in patients. Epilepsy self-management behaviors include activities to manage the disease. The aim of this study was to assess self-management behaviors and its correlation with seizure frequency in patients with epilepsy. Materials and Methods: In this correlation study, 120 patien...
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AIMS Epilepsy affects 0.5-1% of the world's population, and approximately a third of these patients are refractory to current medication. Given their ability to proliferate, differentiate and regenerate tissues, stem cells could restore neural circuits lost during the course of the disease and reestablish the physiological excitability of neurons. This study verified the therapeutic potential o...
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Stress is the most commonly reported precipitating factor for seizures in patients with epilepsy. Despite compelling anecdotal evidence for stress-induced seizures, animal models of the phenomena are sparse and possible mechanisms are unclear. Here, we tested the hypothesis that increased levels of the stress-associated hormone corticosterone (CORT) would increase epileptiform activity and spon...
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Alterations in the balance of K-Na-2Cl cotransporter (NKCC1) and Na-Cl cotransporter (KCC2) activity may cause depolarizing effect of γ-aminobutyric Acid (GABA), and contribute to epileptogenesis in human temporal lobe epilepsy. NKCC1 facilitates accumulation of chloride inside neurons and favors depolarizing responses to GABA. In the current pilot study we provide the first documented look at ...
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ژورنال
عنوان ژورنال: Epilepsia
سال: 2012
ISSN: 0013-9580
DOI: 10.1111/j.1528-1167.2012.03436.x